Hemostasis is the phenomenon of interaction between platelets, blood vessels and coagulation protein which helps to stop the bleeding. In addition, this process also maintains the blood flow in the blood vessels. Bleeding disorders could be a result of vascular and coagulation abnormalities. Hemostasis diagnostics helps in detection of these abnormalities and assists in proper treatment. Hemostasis diagnostic tests include Activated Partial Prothrombin Time (APPT), Prothrombin time (PT), and Fibrinogen assay. PT test is performed by extraction of the blood sample and then blood cells are separated from the blood through centrifugation process. The patient’s plasma is then added to these cells to convert prothrombin to thrombin through tissue factors (V, VII and X) present in the plasma. This helps in detection of factors V, VII and X, Fibrinogen and Prothrombin in the blood sample. This test thus assists in the detection of hemostasis disorders. However in APPT, kininogen, prekallikrein are added to the blood cells which converts factor XI to XIa and helps in detection of any the abnormality related to the absence of XIa. In fibrinogen assay, plasma, bovine and imidazole buffered saline solutions are used to quantify fibrinogen content in blood sample.
Hemostasis disorder results in venous thromboembolism, acute coronary syndrome, dessiminated intravascular coagulation and postsurgical bleeding. Various cancers such as breast, kidney, liver, blood and lungs cancer are the major cause of hemostasis disorders. Amongst all these, liver cancer increases the risk of hemostasis disorders since it produces most clotting factors and inhibitors. In addition, it also produces numerous proteins which are involved in the process of fibrinoysis. In 2012, it has been estimated that around 120,000 people were suffering from liver cancer and is expected to grow exponentially. This exponential growth of liver cancer would augment the growth of hemostasis diagnostics market. Moreover, rise in aging population worldwide is increasing the accidental rate such as falling and injuries would also support the growth of this market. Hemostasis diagnostic tests are also performed prior to operation to test for quick healing process. This would also boost the growth of hemostasis diagnostic market worldwide.
Some of the market players in homeostasis diagnostic market globally include Abbott Laboratories, Siemens Inc., Beckman Coulter and Danaher Corporation, Instrumentation Laboratory and others.
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